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pentobarbital will lessen the extent or impact of capivasertib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Solid or average CYP3A inducers lower capivasertib exposure, which may lessen efficacy.Monitor Closely (one)pentobarbital will lower the extent or impact of tofacitinib by impacting hepatic/intestinal